The exogenous enzyme use is an alternative to increase ingredients digestibility and interest is growing in the use of enzymes to improve animal performance. One of the responses to dietary changes at weaning is the modification of the epithelium structure1. Absorption in the small intestine depends on the villus-crypt relation. The objective of the present study was to investigate the effect of multi-enzyme preparations in the growth performance and jejunum morphology in weaned pigs fed a wheat-barley diet.